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Tumor microenvironment controls the rate of cancer progression and metastasis

Tumors are unorganized organs that contain many different cell types that communicate with cancer cells (Kalluri NRC 2006). The central goal of our laboratory is to evaluate the role of these non-cancer cells in cancer progression and metastasis. Cancer progression significantly depends on the influence of many different host cells. Whether such host responses are recruited to control cancer progression or further aid in tumor growth (or both) is still unclear. This lecture will highlight the role of extra-cellular matrix, angiogenesis, and mesenchymal cells in cancer progression and metastasis, and discuss treatment strategies.

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Correspondence to Raghu Kalluri.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kalluri, R. Tumor microenvironment controls the rate of cancer progression and metastasis. BMC Proc 4 (Suppl 2), O11 (2010). https://doi.org/10.1186/1753-6561-4-S2-O11

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  • DOI: https://doi.org/10.1186/1753-6561-4-S2-O11

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