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BMC Proceedings

Open Access

Tumor microenvironment controls the rate of cancer progression and metastasis

BMC Proceedings20104(Suppl 2):O11

Published: 24 September 2010


Public HealthCancer CellTumor GrowthTreatment StrategyHost Cell

Tumors are unorganized organs that contain many different cell types that communicate with cancer cells (Kalluri NRC 2006). The central goal of our laboratory is to evaluate the role of these non-cancer cells in cancer progression and metastasis. Cancer progression significantly depends on the influence of many different host cells. Whether such host responses are recruited to control cancer progression or further aid in tumor growth (or both) is still unclear. This lecture will highlight the role of extra-cellular matrix, angiogenesis, and mesenchymal cells in cancer progression and metastasis, and discuss treatment strategies.

Authors’ Affiliations

Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston


© Kalluri; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.