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  • Open Access

A new anti-malarial drug against murine malaria

  • 1Email author,
  • 4,
  • 2,
  • 1,
  • 4,
  • 1,
  • 1,
  • 3,
  • 1,
  • 1 and
  • 1
BMC Proceedings20115 (Suppl 1) :P17

https://doi.org/10.1186/1753-6561-5-S1-P17

  • Published:

Keywords

  • Enzyme Activity
  • Survival Rate
  • Malaria
  • Plasmodium
  • Murine Model

Eosin B, a common laboratory dye has been earlier reported to have good anti protozoan properties in vitro. We studied this drug for its effect on a murine malaria strain, Plasmodium berghei (Pb) in vivo using different tests. Full suppressive 4 days Peter’s Test was used in infected outbred and inbred mice, using both ip and oral routes. Secondary biological assessment was carried out using dose ranging, ED50 and ED90 values obtained. Eosin B anti malarial activity at 400 Ug/ml given in both the routes was similar to that of artemisine and mice survival rate was double that of control and 3 days more than artemisine. PbGST activity was monitored and it was seen that eosin B lowered this enzyme activity. Eosin B seems to be a promising drug, exhibiting good anti malarial effects in the murine model of disease.

Authors’ Affiliations

(1)
Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran
(2)
Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran
(3)
Department of Clinical Reaserch, Pasteur Institute of Iran, Tehran, Iran
(4)
Department of Biochemistry, Payame Noor University of Tehran, Iran

Copyright

© Zamani et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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