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BMC Proceedings

Open Access

Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease

  • Jonathan Cechetto1,
  • Hee Kyoung Jeon1,
  • Jiyeon Jang1,
  • Doyoon Kwon1,
  • Thierry Christophe1,
  • Priscille Brodin2,
  • Gyongseon Yang3,
  • Jair Neto3 and
  • Lucio Freitas Junior3
BMC Proceedings20115(Suppl 1):P38

Published: 10 January 2011


TuberculosisSmall MoleculeActive CompoundDrug DiscoveryLeishmaniasis

There is a pressing, global need for new therapies for neglected diseases such as Tuberculosis, Leishmaniasis and Chagas. Traditional lead discovery approaches, while effective have not been widely applied to neglected diseases as they are expensive and time consuming. At Institut Pasteur Korea, we have developed a core technology that enables the high content screening of hundreds of thousands of small molecules against the disease of interest. In doing so, we utilize relevant disease models that allow us to interrogate the disease in the context of the cell and the host-pathogen factors required for invasion, replication, persistence and release. The application of this core technology against Tuberculosis, Leishmaniasis and Chagas disease has resulted in the identification of novel, active compounds in less time and at less cost than traditional drug discovery methods. As these active compounds were identified in a cellular context, they can provide a more relevant starting point for new therapies.

Authors’ Affiliations

Screening Technology Platforms, Institut Pasteur Korea, Seongnam-si, Korea
Biology of Intracellular Pathogens, Institut Pasteur Korea, Seongnam-si, Korea
Center for Neglected Diseases, Institut Pasteur Korea, Seongnam-si, Korea


© Cechetto et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.