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Prevalence and acquisition rate of extended spectrum beta lactamase producing gram-negative organisms (ESBL-GNO) in general medical patients in Switzerland

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Introduction / objectives

We aimed to determine the prevalence and acquisition rate of ESBL-GNO amongst patients admitted to general medical units at our hospital.

Methods

Patients consecutively admitted to 13 medical wards from March-June 2010 were screened for ESBL-GNO via rectal swab within 48hours of admission, and 36 hours of discharge.

Results

Of 1967 patients, swabs were obtained in 1111(56%) at admission and 491(25%) at discharge with 441(22%) having both. Mean age was 64 years and 58% were male. 6.8% (75/1111) of patients were positive for an ESBL-GNO at admission of whom 86%, for whom data were available (24/28), had an ESBL-GNO detected in the previous 6 months. 3.7%(18/487) of patients acquired an ESBL-GNO, having positive cultures at discharge but not at admission. On univariate regression, acquisition of an ESBL-GNO was associated with admission from home (OR 0.2 [95%CI 0.1-0.6], p=.005), transfer from another unit (OR 8.3[95% CI 2-33], p=.003) and receipt of a first or second-generation cephalosporin (OR 7.2 [95% CI 1-37],p=.017). Receipt of a first or second-generation cephalosporin was the only factor independently associated with ESBL-GNO acquisition (OR 7.1[95% CI 1-40], p=.03). Age, sex, intensive care, provenance and receipt of other antibiotics were not associated with ESBL carriage or acquisition.

Conclusion

Carriage and acquisition of ESBL-GNO is a problem amongst medical patients at our hospital. No risk factors for ESBL-GNO carriage were identified.

Disclosure of interest

None declared.

Author information

Correspondence to J Pasricha.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pasricha, J., Koessler, T., Camus, V. et al. Prevalence and acquisition rate of extended spectrum beta lactamase producing gram-negative organisms (ESBL-GNO) in general medical patients in Switzerland. BMC Proc 5, O24 (2011). https://doi.org/10.1186/1753-6561-5-S6-O24

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Keywords

  • Public Health
  • Cephalosporin
  • Medical Patient
  • Positive Culture
  • Acquisition Rate