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Transmission of KPC producing Klebsiella pneumoniae despite appropriate barrier precautions of an intensive care unit in the Netherlands

Introduction / objectives

Enterobacteriaceae producing carbapenemases are very rare in the Netherlands and correspond almost exclusively to imported clones from endemic areas. Here, we report an imported case of KPC-carrying K. pneumoniae with transmission to another patient.


A 68 year old female who was travelling in Greece was admitted to the ICU of the University Hospital of Ioannina in Greece for urosepsis and hypercapnic coma. The patient was transferred to the ICU of the Spaarne Hospital on September 22nd 2010 (day 9). Patient was admitted in strict barrier precautions for MRSA. Intestinal carriage of MDR Enterobacteriaceae was screened at admission and a carbapenem-resistant K. pneumoniae strain was isolated from a throat swab. A confirmational PCR was positive for blaKPC. On October 14th a routine urine sample from a patient who had been admitted for 15 days at the ICU, tested positive for a genotypically identical KPC producing K. pneumoniae.


Secondary spread was investigated by active surveillance. None of the patients or personnel was found to be positive for KPC-carrying Enterobacteriaceae. No further cases were identified.


Here we report dissemination of KPC-producing K. pneumoniae from a patient repatriated from a Greece ICU despite continuous barrier precautions. We found no evidence for further local spread within our hospital. We stress the importance of early identification and confirmation followed by intensified infection control measures to prevent the dissemination of Enterobacteriaceae with KPC-enzymes.

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None declared.

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Correspondence to B Diederen.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Diederen, B., Hattink, C. & de Groot, M. Transmission of KPC producing Klebsiella pneumoniae despite appropriate barrier precautions of an intensive care unit in the Netherlands. BMC Proc 5, O25 (2011).

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  • Intensive Care Unit
  • Urine Sample
  • Endemic Area
  • Infection Control
  • Active Surveillance