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Risk factors for previously unknown methicillin-resistant Staphylococcus aureus (MRSA) carriage on admission to 13 surgical wards in Europe
BMC Proceedings volume 5, Article number: O85 (2011)
Introduction / objectives
MRSA carriers admitted to surgical wards may pose both clinical and epidemiological problems. We performed a prospective, observational cohort study of patients screened for MRSA on admission to 13 surgical wards in 4 European hospitals, to identify risk factors of previously unknown MRSA carriage and to define a common predictive rule.
Multivariate logistic regression models were used to predict probabilities of MRSA colonization on admission based on patient characteristics. A scoring system was defined based on odds ratio results. The c-statistic was calculated to evaluate several models.
We enrolled 2901 patients, of whom 111 (3.8%) were unknown MRSA carriers on admission. We identified 7 independent risk factors associated for newly identified MRSA carriage on admission: urinary catheter, nursing home residency, chronic skin disease, wounds, recent hospitalization, diabetes, and age ≥70 years. No risk factor was common to all 4 centres. The overall prediction rule with a lower cut-off had 87% sensitivity and 32% specificity, while values for a higher cut-off were 40% and 89%, respectively. Local predictive rules performed slightly better: 56% sensitivity and 96% specificity for Barcelona. The c-statistic for the model including all centres was 0.64, indicating limited predictive power of the common model.
Risk factors for unknown MRSA carriage vary substantially between surgical wards across Europe. A common predictive rule is of limited clinical value.
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Pan, A., Lee, A., Cooper, B. et al. Risk factors for previously unknown methicillin-resistant Staphylococcus aureus (MRSA) carriage on admission to 13 surgical wards in Europe. BMC Proc 5 (Suppl 6), O85 (2011). https://doi.org/10.1186/1753-6561-5-S6-O85
- Nursing Home
- Skin Disease
- Multivariate Logistic Regression Model
- Urinary Catheter
- Observational Cohort Study