Skip to main content

Advertisement

You are viewing the new article page. Let us know what you think. Return to old version

Poster presentation | Open | Published:

Antimicrobial use prior as a risk factor for developing extended-spectrum beta-lactamse-producing Klebsiella spp. in South Brazil

Introduction / objectives

Extended-spectrum beta-lactamase-producing (ESBL) Klebsiella spp. is a problematic nosocomical pathogen around the world. In the present study, we aimed to evaluate the previous use of antibiotics as a risk factor for isolation of ESBL Klebsiella spp.

Methods

In a retrospective case control study between June 2009 and June 2010 at Santa Casa de Misericórdia Hospital, city of Ponta Grossa, south Brazil, 61 Klebsiella spp. (29 ESBL and 32 controls non-ESBL-producing isolates) were enrolled. ESBL were screened by disk diffusion method and double disk approximation method, according to CLSI. Prior use of antibiotic was analyzed in electronic medical records. The antibiotic consumption (DDDs – defined daily doses) was tested using the X2 test (p <0.05).

Results

The DDDs of prior use and full use of cephalosporines, fluoroquinolones, e metronidazole in ESBL and non-ESBL groups were (122.02/145.77; 8.78/69.07), (15.66/22; 0.01/26.2), (47.33/47.66; 3/28) respectively. Prior use of cephalosporines, fluoroquinolones, and metronidazole was higher in ESBL-Klebsiella spp. than non-ESBL-Klebsiella spp. (p<0,001). Carbapenems were not used by the control group.

Conclusion

Theprior use of broad-spectrum cephalosporins, fluoroquinolones and metronidazole is an important risk factor for acquisition of ESBL producing Klebsiella spp.

Disclosure of interest

None declared.

Author information

Correspondence to T Ostroski.

Rights and permissions

Reprints and Permissions

About this article

Keywords

  • Cephalosporin
  • Metronidazole
  • Electronic Medical Record
  • Disk Diffusion
  • Retrospective Case