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Trends in regional outpatient antibiotic prescription data and interventions in the Dutch-German EURSAFETY HEALTH-NET-project

Introduction / objectives

Increasing prescription of broad-spectrum antibiotics is regarded to facilitate selection of multiresistant germs. Surveillance of outpatient antibiotic use might contribute to prevent the spread of Methicillin-resistant S. aureus (MRSA) within the EURSAFETY HEALTH-NET. Training sessions on MRSA and antibiotic awareness were offered to general practitioners. A possibility for reimbursement of MRSA eradication therapy in outpatients has been created.


Regional data for outpatient prescription of antibiotics (based on Defined Daily Doses (DDD)) were collected by the Association of Statutory Health Insurance Physicians Westphalia-Lippe (KVWL) and analyzed for the years 2002 to 2009. In order to compare the prescription of different antibiotics like fluoroquinolones or mupirocin in the EUREGIO to the whole KVWL region, we used the Cochrane Armitage Trend Test.


Altogether, a total of 12.2 DDD / day per 1,000 inhabitants (DID) were prescribed in 2002, followed by 12.9 DID, 12.9 DID, 14.4 DID, 13.8 DID, 14.4 DID, 14.7 DID and 14.8 DID from 2003 to 2009, respectively. From 2002 to 2009 the percentage of prescriptions of all antibiotics and of fluorochinolones decreased significantly in EUREGIO relating to the whole KVWL region. In contrast, the number of mupirocin prescriptions increased significantly more in EUREGIO than in KVWL region.


As desirable, EUREGIO tends to prudent antibiotic use. The increasing number of mupirocin prescription among outpatients reflects the growing demand and, facilitated by new refunding possibilities, the increasing implementation of MRSA eradication therapy in outpatient care.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jurke, A., Flume, M., Köck, R. et al. Trends in regional outpatient antibiotic prescription data and interventions in the Dutch-German EURSAFETY HEALTH-NET-project. BMC Proc 5 (Suppl 6), P144 (2011).

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  • Public Health
  • Health Insurance
  • General Practitioner
  • Training Session
  • Regional Data