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Absence of Clostridium difficile stool carriage in asymptomatic volunteers
BMC Proceedings volume 5, Article number: P183 (2011)
Introduction / objectives
Clostridium difficileÂ is considered a leading cause of hospital-acquired diarrhea. Currently there areÂ published case-reports of symptomatic Health-Care-Workers (HCW)Â and one report demonstratingÂ transmission of C. diff from patient to HCW. Therefore, we initiated a prospective study to evaluate the prevalence of asymptomatic C. difficile stool carriage among healthcare workers at a single university hospital comparing themÂ to non-healthcare workers to asses the risk for HCW’s acquiring Clostridium difficile.
The study population consisted of 113 healthy HCW’s of clinical departments with a high incidence ofÂ CDI in inpatients. The 128 controls were taken from the administration department of a Food Company and from frozen stool samples of healthy subjects from a colon cancer screening program. Both groups were comparable in age-and sex-distribution. From April to July 2010, in total 241 stool specimens were tested for toxigenic culture of C diff.. 51% of stool samples (58/113) of the study population and all control-samples (n=128) were confirmed by broth enrichment technique at the National Reference Laboratory for C. difficile in Vienna.
Both investigated study-groups (n-total = 241) were negative for Clostridium difficile by both culture techniques (direct plating and broth enrichment method).
We conclude, therefore, that healthy HCWs are probably not at risk for aquiring C diff spores from contacts with CDI-patients. They are themselves no risk for spreading C. diff spores in health-care facilities. Data about C.diff carriage in the community (up to 3%) demonstrates a possible overestimation.
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Hell, M., Sickau, K., Chmelizek, G. et al. Absence of Clostridium difficile stool carriage in asymptomatic volunteers. BMC Proc 5 (Suppl 6), P183 (2011). https://doi.org/10.1186/1753-6561-5-S6-P183
- Stool Sample
- Clostridium Difficile
- Stool Specimen
- Cancer Screening Program
- Enrichment Method