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  • Poster presentation
  • Open Access

Central line associated blood stream infectious cause by multi drug resistance coagulaso-negative Staphylococci in newborns from neonatial intensive care units in Poland

  • 1,
  • 1,
  • 2,
  • 3,
  • 4 and
  • 1
BMC Proceedings20115 (Suppl 6) :P205

  • Published:


  • Macrolides
  • Neonatial Intensive Care Unit
  • Multi Drug Resistance
  • Blood Stream Infection
  • Polymicrobial Infection

Introduction / objectives

The project aims to analyze epidemiology and microbiology of Central Line Associated Blood Stream Infections (CLABSI) cause by Multi Drug Resistance Coagulaso-Negative Staphyloccoci (MDRCoNS) in children with very low birth weight (VLBW).


Data collection on CLABSI in VLBW newborns was made prospectively for 2009 year. Study covered 386 neonates of birth weight <1500g in 2 Polish NICUs (A and B), among which 55 cases of CLABSI were detected. CoNS strains isolated from 26 newborns with CLABSI, were determined in blood in the automatic system Vitek, drug resistance was determined by disc diffusion method.This study was supported by a grant no. NN401615340.


Birth-weight and gestational age were significantly different between newborns in NICU-A and B (P<0.01). The CLABSI incidence per 1000 CVC/pds (patient days) in NICU-A and B were 8.5 and 5.2, respectively (RR1.6). CVC utilization in NICU-A and NICU-B were 0.5 and 0.4, respectively. The most common etiological factors of CLABSI were CoNS (66%). The dominant species were S.epidermidis (63%), S.haemolityicus (20%), S.warneri (8%), S.hominis (5%), S.xylosus (2%) and S.capitis (2%). Among 26 newborns with CoNS BSI, 2 children had polymicrobial infections caused by S. haemolyticus and S. epidermidis. Resistance to methicillin, macrolides, aminoglycosides and fluoroquinolones was detected in 98%, 70%, 78% and 43% of isolates, respectively. All methicillin resistant CoNS strains had mecA gen.


Understanding the epidemiology of CLABSI in VLBW neonates is a key step in development of targeted prevention strategies and reduce antibiotic consumption.

Disclosure of interest

None declared.

Authors’ Affiliations

Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland
Neonatal and Intensive Care Department, Medical University of Warsaw, Poland
Duchess Anna Mazowiecka, Teaching Hospital, Warsaw, Poland
Polish Mother`s Memorial Hospital, Lodz, Poland


© Brzychczy-Wloch et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.