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Lupoid cutaneous leishmaniasis in Afghanistan treated with 0.045% DAC N-055
BMC Proceedings volume 5, Article number: P247 (2011)
Introduction / objectives
Lupoid leishmaniasis (LCL) is a rare, face disfiguring, treatment resistant complication which has responded to the expensive photodynamic therapy in 5 patients in Iran [ F. Ghaffarifar et al. La Rev. de la Méditerranée orientale Vol. 12 No. 6, 2006]. Here we report 5 cases,- photodocumented as best as we could under the actually disastrous conditions of Afghan Health Care,- treated with 0.045% DAC N-055 [German Drug Codex, 1990], which is split into 1O2 and 2NaClO2 after 360 nm light exposure and reacts as chlorite in iodometry.
The faces of 5 patients with a CL anamnesis and clinically diagnosed as lupoïd CL were treated daily for the first week with 0.045 % DAC N-055 prepared in basic crème DAC B-20 under occlusive dressings, thereafter the patients were instructed to treat themselves with this hydrophilic crème and were told to show up as outdoor patients at least once per fortnight. Pharmaceutical chlorite, NaClO2 [monograph DAC N-055] is O2 enriched due to its Na2Cl2O6 content, formerly called TCDO, (NaClO2)4·O2, which fights viral, bacterial or parasitic tissue infections and promotes wound granulation even in radiogenic ulcers [http://www-pub.iaea.org/mtcd/publications/pdf/te_1300_web.pdf].
1 patient was lost, 4 patients healed completely without scarring and with excellent cosmetic results (see photos!), 3 within 3 months, 1 after 10 months because of an additional severe eczema. There were no clinical signs of recurrence, one patient was followed for 6 years.
The low treatment costs for such excellent cosmetic results are appropriate for poor Afghan patients.
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Stahl, K., Sakhayeee, I. Lupoid cutaneous leishmaniasis in Afghanistan treated with 0.045% DAC N-055. BMC Proc 5 (Suppl 6), P247 (2011). https://doi.org/10.1186/1753-6561-5-S6-P247
- Public Health
- Clinical Sign
- Treatment Cost
- Photodynamic Therapy
- Tissue Infection