Fist case of laboratory confirmed BCG infection following vaccination in children in Albania
© Tafaj and Kasmi; licensee BioMed Central Ltd. 2011
Published: 29 June 2011
Introduction / objectives
The attenuated bacilli Calmette-Guerin (BCG) vaccine is administered in Albania to all newborns at the first day of life to prevent tuberculosis. Although complications are rare after BCG vaccination and the outcome is usually favourable, serious BCG infections can occur. The risks associated with BCG vaccination include local complications, extraregional localized disease, and disseminated BCG disease.
We report a case of M. bovis BCG infection in an 11-month old immunocompetent girl. The child was referred to the National TB Reference Laboratory by the pediatrician to perform smear examination and culture for mycobacteria from supurated cervical lymph node.
The smear result was positive for acid-fast bacilli and culture of specimen resulted positive for mycobacteria fully susceptible to rifampicin, isoniazid and ethambutol, but resistant to pyrazinamide. M. bovis BCG was identified by using a commercial identification kit (Genotype MTBC kit-Hain LifeScience). The VNTR-MIRU genotyping and spoligotyping of the isolate DNA was performed subsequently. The child was sent by her parents abroad and the treatment outcome is not known to us so far.
To our knowledge this is the very first case of laboratory proven BCG infection following vaccination in children in Albania. Although BCG is considered to be a safe vaccine, it should be kept in mind that complications related to BCG do occur especially in children with cellular immunodeficiencies. Prevalence of BCG disease in Albania is not exactly known.
Disclosure of interest
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.