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Mluti-faceted interventions to prevent bloodstream MRSA infections

Introduction / objectives

From 1st January until 31st December 2007, there were 31 MRSA bacteraemias at our NHS Trust. 22 were defined as HAI. It was discovered that the source of the MRSA bacteraemias in 12 (54%) of the patients was due to PIVD (Peripheral Intravascular Devices).


The introduction of a sequence of interventions targeted at reducing MRSA bacteraemias by a newly expended infection control team, after analysis of existing polices and procedures.

The use of MRSA antimicrobials in the Trust's formulary was optimised. Teicoplanin was substituted with daptomycin in medical and surgical wards. In Intensive Care vancomycin by continuous infusion was introduced.

Introduction of MRSA screening of all adult emergency admissions and subsequent decolonisation of patients of patients found to be positive.

A new PIVD policy, insertion record and on-going care tool was launched. Skin preparation was changed from a non-sterile 70% alcohol and 0.5% chlorhexidine swab, to a sterile pre packaged application device containing 70% alcohol and 2% chlorhexidine.

Mechanical Needle-free connectors were replaced with split septum connectors.


Introduction of these 4 interventions were plotted chronologically against the cumulative MRSA bacteraemia rates and calculated per 10,000 bed days. The implementation of the 4 interventions were successful in controlling the cumulative rate of MRSA bacteraemia.


The expansion of the infection control team triggered a review of procedures in our Trust. 4 Interventions were instituted to comply with best practice. Each intervention could not be shown to be effective individually, partly as the monthly rates of bacteraemias were consistently low and partly as each new intervention was introduced in quick succession.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Orsman, P., St Andre, J., Smith, I. et al. Mluti-faceted interventions to prevent bloodstream MRSA infections. BMC Proc 5 (Suppl 6), P59 (2011).

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  • Vancomycin
  • Teicoplanin
  • Chlorhexidine
  • Daptomycin
  • Emergency Admission