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Use of chlorhexidine-impregnated dressing in neonates


Catheter–related bloodstream infection (CR-BSI) is a significant cause of morbidity and mortality in the NICU. The chlorhexidine-impregnated dressing (CHID) has proven effective in reducing the colonization catheter tip and CR-BSI.


Describe the experience on using CHID (Biopatch®) on the central venous catheter (CVC) in neonates at a 70 beds NICU.


The NICU has a group responsible for the insertion and maintenance of CVC according to the standards recommendation from CDC.InMay2010we startedusing the CHID in all neonates weighing > 1500g and gestational age > 34 weeks. The dressing was replaced weekly. The observation was conducted from May to December 2010. Besides the new dressing, we also changed from 70% alcohol to alcoholic chlorhexidine solution for disinfection of the CVC hub.


Sixty-four neonates were enrolled in the trial. There was no CR-BSI in neonates weighing > 1500g after the introduction of the CHID (0 / 1089 cvc /day). Compared to the same period in 2009 (without Biopatch), the rate of CR-BSI was 3.2 (6 / 1833 cvc / day). One neonate developed localized contact dermatitis with absolute regression after removal of the dressing.


We are not able to affirm that this intervention was responsible for the decrease of CR_BSI rate, but these dataisencouraging. Local contact dermatitis was not a problem. There was a good acceptance of the new dressing by the nursing staff. Apparently the CHID is safe and significantly reduces the rates of CR-BSI in neonates.

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Richtmann, R., Silva, C., Baltieri, S. et al. Use of chlorhexidine-impregnated dressing in neonates. BMC Proc 5 (Suppl 6), P61 (2011).

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