Table 1 Differentially-expressed genes in hirsein B-treated B16 murine melanoma cells as determined by DNA microarray.
Biological Process | Differentially expressed genes | Up- or Down- regulated |
|---|---|---|
Melanin biosynthesis | Mitf, Mc1r | Downregulated |
Melanosome transport | Rab27a, Mlph, Myo5A, Myo7A | Downregulated |
Negative regulation of transcription from RNA polymerase II promoter | Sorbs3 | Downregulated |
Wnt signaling pathway | Ppap2b, Wisp, Kremen1 | Upregulated |
Cell cycle regulation | Gadd45b, Csnkl | Upregulated |
Activation of MAPK signaling pathway | Gadd45b , Pxn, Map2k3, Met, Avpi1, Spag9 | Upregulated |
Cytoskeleton organization | Pxn | Upregulated |
Protein phosphorylation | Mapkapk3 | Upregulated |