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Table 1 Q1 single replicate results for combined populations (200 replicates, N = 697 each)

From: Stratify or adjust? Dealing with multiple populations when evaluating rare variants

  

Count (quantitative)

Indicator (dichotomous)

Gene

Chromosome

Median (p)

Min, max

Median (p)

Min, max

FLT1

13

3.1 × 10−19

1.1 × 10−29, 5.0 × 10−10

9.7 × 10−19

9.2 × 10−30, 1.2 × 10−10

ZNF605

12

7.2 × 10−10

5.0 × 10−19, 1.8 × 10−4

7.2 × 10−10

5.0 × 10−19, 1.8 × 10−4

TAS2R48

12

8.1 × 10−9

9.4 × 10−16, 2.0 × 10−2

3.0 × 10−8

4.8 × 10−15, 2.3 × 10−2

ZNF84

12

1.4 × 10−8

8.5 × 10−18, 1.7 × 10−3

1.4 × 10−9

8.5 × 10−18, 1.7 × 10−3

  1. Linear regression results from using two collapsing approaches for rare variants in a gene. Analyses used population as a covariate. The median, minimum (min), and maximum (max) p-value for each gene that passed our threshold of 10−6 for at least 50% of the replicates are listed.
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BMC Proceedings

ISSN: 1753-6561

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