Comparison of results from tests of association in unrelated individuals with uncollapsed and collapsed sequence variants using tiled regression

Table 2 Average proportion of 200 replicates identifying noncausal variants in traits Q1, Q2, and Q4

Trait	PoR for uncollapsed variants			PoR for collapsed variants (MAF < 0.01 and nonsynonymous)
	TR 10⁻²	TR 10⁻⁷	SLR 10⁻⁷	TR 10⁻²	TR 10⁻⁷	SLR 10⁻⁷
Q1	9.7 × 10⁻⁴	5.5 × 10⁻⁶	6.8 × 10⁻⁴	1.3 × 10⁻³	7.3 × 10⁻⁶	1.0 × 10⁻³
Q2	1.3 × 10⁻³	6.2 × 10⁻⁶	3.1 × 10⁻⁶	1.7 × 10⁻³	3.8 × 10⁻⁶	2.1 × 10⁻⁶
Q4	1.3 × 10⁻³	3.5 × 10⁻⁶	2.0 × 10⁻⁷	1.7 × 10⁻³	3.2 × 10⁻⁶	0.0

TR, tiled regression. SLR, simple linear regression. PoR, proportion of 200 replicates. For the tiled regression, 10⁻² and 10⁻⁷ are the critical values; for the simple linear regression, 10⁻⁷ is the significance level.

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