Identifying causal rare variants of disease through family-based analysis of Genetics Analysis Workshop 17 data set

Table 2 Top candidate genes from separate pedigrees

Pedigree 1	p-value	Pedigree 3	p-value	Pedigree 4	p-value	Pedigree 5	p-value
GPR115	0.000004	KDR	0.00000002	EPHA6	0.0052	PIBF1	0.0003
C6orf130	0.000013	KIT	0.00000002	GPR128	0.0052	CCNA1	0.0009
GUCA1B	0.000013	LNX1	0.00000002	OR5K1	0.0052	CYSLTR2	0.0009
KIAA0240	0.000013	PDGFRA	0.00000002	OR5K2	0.0052	DGKH	0.0009
MEA1	0.000013	SGCB	0.00000002	OR5K3	0.0052	DNAJC15	0.0009
PPP2R5D	0.000013	SPATA18	0.00000002	OR5K4	0.0052	ELF1	0.0009
PRPH2	0.000013	PPAT	0.00000045	ST3GAL6	0.0052	FNDC3A	0.0009
PTK7	0.000013	SPINK2	0.00000045	B3GALTL	0.0054	FREM2	0.0009
RGL2	0.000013	GUF1	0.00005598	BRCA2	0.0054	HTR2A	0.0009
SLC26A8	0.000013	NFXL1	0.00005598	FLT1	0.0054	NUFIP1	0.0009
TAF11	0.000013	CHRNA9	0.00047549	LOC650794	0.0054	P2RY5	0.0009
TBCC	0.000013	NSUN7	0.00047549	SGCG	0.0054	RB1	0.0009
TFEB	0.000013	RHOH	0.00047549	TNFRSF19	0.0054	RCBTB2	0.0009
ZNF76	0.000013	LZTR1	0.00167619	ZMYM2	0.0054	TRPC4	0.0009
NFKBIE	0.000014	SCARF2	0.00167619	ZMYM5	0.0054	FLT1	0.0010
RUNX2	0.000014	SDF2L1	0.00167619	NFKBIZ	0.0092	STARD13	0.0011
SUPT3H	0.000014	TOP3B	0.00167619	STARD13	0.0208	B3GALTL	0.0013
VEGFA	0.000014	JMJD2C	0.00242110	ATP10A	0.0213	BRCA2	0.0013
HFE	0.000019	PTPRD	0.00242110	ADCY5	0.0229	LOC650794	0.0015
HIST1H2AA	0.000019	KIAA1432	0.00303729	ADPRH	0.0229	SGCG	0.0015

Linkage analysis results of top candidate genes by regressing the square of the difference of Q1 against IBD for all sib pairs in a pedigree.

ISSN: 1753-6561