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Table 3 P-values corresponding to the true causal genes using Q1 as phenotype

From: Identifying causal rare variants of disease through family-based analysis of Genetics Analysis Workshop 17 data set

Chromosome

Gene

1% cutoff

3% cutoff

  

Nuclear families

Pedigrees

Nuclear families

Pedigrees

1

ARNT

0.441

0.301

0.450

0.406

1

ELAVL4

0.447

0.347

0.952

0.948

4

KDR a

0.03

0.09

0.229

0.092

4

VEGFC a

0.009

0.317

0.009

0.317

5

FLT4

0.314

0.299

0.319

0.304

6

VEGFA a

0.0002

0.122

0.002

0.156

13

FLT1 a

0.076

0.128

0.0003

0.024

14

HIF1A

NA

NA

0.317

0.317

19

HIF3A

0.508

0.466

0.638

0.609

  1. a Gene that has polymorphic causal SNPs. The other five causal genes (not marked by superscript a) cannot be identified in our method because there were no causal SNPs corresponding to those genes in the sample.
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BMC Proceedings

ISSN: 1753-6561

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