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Table 3 p-Values for testing pathway and gene effects for data sets

From: Pathway analysis for family data using nested random-effects models

Gene

Binary outcome

Quantitative trait Q1

 

Unrela

FAMb

Unrela

FAMb

ARNT

0.13

0.12

0.27

0.76

ELAVL4

0.14

0.55

0.31

0.15

FLT1

0.32

0.44

0.01

0.84

FLT4

0.77

0.11

0.32

1.6 × 10−8

HIF3A

0.69

0.62

0.07

0.04

KDR c

0.26

0.53

0.35

0.89

Interactiond

0.86

0.38

0.24

0.68

VEGFA

0.45

0.10

0.26

0.004

VEGFC

0.98

0.42

0.69

6.8 × 10−7

Pathway

0.51

0.002

0.06

4.9 × 10−10

  1. a Based on genotypes of 697 unrelated individuals.
  2. b Based on 140 sibships.
  3. c Two degrees of freedom tests (including interaction term).
  4. d p-value for interaction term.
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BMC Proceedings

ISSN: 1753-6561

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