Figure 4From: Use of principal components to aggregate rare variants in case-control and family-based association studies in the presence of multiple covariatesTop 30 genes associated with Q1 using the weight-based and step-up methods with a case-control design. (a) Weight-based method adjusting for age, sex, population, and smoking. (b) Step-up method adjusting for age, sex, population, and smoking. Box plots represent the distribution of the 200 P-values of the 200 replicates for the 30 genes with the highest median P-values.Back to article page