Table 2 Gene-phenotype association analysis using population-based data
From: Family- and population-based designs identify different rare causal variants
Gene | Number of SNPs | Number of causal SNPs | Causal/total SNPs (%) | Number of simulations with gene detected at α = 0.01 | Number of simulations with gene detected at α = 0.0001 | ||||
|---|---|---|---|---|---|---|---|---|---|
Binary | Percent | Sum test | Binary | Percent | Sum test | ||||
ARNT | 8 | 4 | 50 | 2 | 2 | 3 | 0 | 0 | 0 |
ELAVL4 | 3 | 2 | 67 | 2 | 2 | 2 | 0 | 0 | 0 |
FLT1 | 17 | 8 | 47 | 111 | 111 | 115 | 19 | 19 | 23 |
FLT4 | 5 | 2 | 40 | 0 | 0 | 5 | 0 | 0 | 0 |
HIF1A | 5 | 3 | 60 | 3 | 3 | 2 | 0 | 0 | 0 |
HIF3A | 6 | 3 | 50 | 0 | 0 | 1 | 0 | 0 | 0 |
KDR | 9 | 8 | 89 | 98 | 162 | 151 | 17 | 52 | 55 |
VEGFA | 2 | 1 | 50 | 16 | 16 | 20 | 1 | 1 | 1 |
VEGFC | 1 | 1 | 100 | 86 | 86 | 86 | 11 | 11 | 11 |