Table 2 Statistics aggregated across populations

Gene	Mean Tajima’s D	Variance of Tajima’s D	Total number of variants	Proportion of rare variants	Proportion of rare variants that are nonsynonymous
Nonsynonymous
AHNAK	−2.08	0.06	65.86	0.86	0.69
RELN	−1.97	0.02	33.43	0.74	0.59
POLE	−1.95	0.04	24.29	0.72	0.69
PIK3C2B	−1.83	0.19	21.29	0.62	0.56
PKD1	−1.49	0.39	22.86	0.71	0.61
RANBP2	NA	NA	24.57	0.82	NA
INVS	−1.72	0.22	9.43	0.82	0.75
NPC1L1	−1.70	0.10	13.71	0.83	0.58
BAIAP3	−1.73	0.05	13.29	0.81	0.63
RGPD4	−1.16	0.83	18.86	0.83	0.62
CEP250	−1.59	0.06	17.14	0.85	0.65
ATM	−1.38	0.19	5.29	0.95	0.77
GAB2	NA	NA	9.14	0.54	NA
DNMBP	−1.82	0.04	19.43	0.69	0.66
OR8H1	−1.24	0.29	6.86	0.63	0.93
CCDC63	−1.64	0.04	8.00	0.90	0.77
Average	−1.66	0.18	19.59	0.77	0.68
Synonymous
TACC2	−1.20	0.36	36.71	0.67	0.63
FRMPD2	−1.21	0.48	14.14	0.78	0.47
VPS26A	−1.33	0.36	0.57	NA	NA
MDN1	−1.20	0.95	54.29	0.71	0.64
PTPRS	−1.21	0.36	18.86	0.78	0.37
RGPD4	−1.62	0.13	18.86	0.83	0.62
C20ORF26	−0.89	1.48	21.71	0.73	0.71
H2AFY2	NA	NA	3.29	NA	NA
Average	−1.24	0.59	21.05	0.75	0.57

Tajima’s D, its variance, total number of polymorphisms, and the proportions of rare and nonsynonymous variants are given for each of the genes that reflect the most negative values of Tajima’s D(less than −2 for the analysis based on nonsynonymous SNPs and less than −1.8 for the analysis based on synonymous SNPs). NA (not applicable) corresponds to instances in which the value is not defined for at least one of the populations.

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