Table 2 Significant GO processes
From: A weighted accumulation test for associating rare genetic variation with quantitative phenotypes
GO term | Description | Permutation p-value (weighted approach) | Permutation p-value (unweighted approach) |
|---|---|---|---|
GO:0000186†| Activation of MAP kinase activity, especially during sporulation | <1.0 × 10–6 | 4.0 × 10–5 |
GO:0001569†* | Branching involved in blood vessel morphogenesis | <1.0 × 10–6 | <1.0 × 10–6 |
GO:0001666†* | Response to lowered oxygen tension | <1.0 × 10–6 | 1.0 × 10–6 |
GO:0001938†* | Up-regulation of endothelial cell proliferation | <1.0 × 10–6 | <1.0 × 10–6 |
GO:0002040†* | Sprouting angiogenesis | <1.0 × 10–6 | <1.0 × 10–6 |
GO:0006355†* | Regulation of cellular transcription, DNA-dependent | <1.0 × 10–6 | <1.0 × 10–6 |
GO:0006916* | Anti-apoptosis | 7.5 × 10–5 | 1.0 × 10–6 |
GO:0006940†* | Any process that modulates the frequency, rate, or extent of smooth muscle contraction | <1.0 × 10–6 | <1.0 × 10–6 |
GO:0006952 †| Defense/immunity protein activity | 8.0 × 10–6 | 1.9 × 10–5 |
GO:0007169†* | Transmembrane receptor protein tyrosine kinase signaling pathway | <1.0 × 10–6 | <1.0 × 10–6 |
GO:0008152†| Metabolic process | 3.0 × 10–6 | 2.2 × 10–5 |
GO:0010595†* | Up-regulation of endothelial cell migration | <1.0 × 10–6 | 7.0 × 10–6 |
GO:0030097†| Blood cell formation | <1.0 × 10–6 | (a) |
*GO:0030522†* | Intracellular receptor-mediated signaling pathway | <1.0 × 10–6 | <1.0 × 10–6 |
GO:0030949†* | Up-regulation of vascular endothelial growth factor (VEGF) receptor signaling pathway | <1.0 × 10–6 | <1.0 × 10–6 |
GO:0043129†* | Surfactant homeostasis | <1.0 × 10–6 | 1.1 × 10–5 |
GO:0045446†| Endothelial cell differentiation | <1.0 × 10–6 | (a) |
GO:0045745* | Positive regulation of G-protein coupled receptor protein signaling pathway | 6.425 × 10–2 | 1.2 × 10–5 |
GO:0048286†* | Lung alveolus development | <1.0 × 10–6 | 5.0 × 10–6 |
GO:0048661†* | Up-regulation of smooth muscle cell proliferation | <1.0 × 10–6 | <1.0 × 10–6 |
GO:0050927†| Up-regulation of positive chemotaxis | <1.0 × 10–6 | (a) |
GO:0051894†| Up-regulation of focal adhesion formation | <1.0 × 10–6 | (a) |
GO:0055074†| Regulation of calcium ion concentration | <1.0 × 10–6 | (a) |