Identity-by-descent filtering as a tool for the identification of disease alleles in exome sequence data from distant relatives

Table 3 Top 43 genes from the IBD analysis

Gene	Observed number of phenotype files
F5	140
NF2	136
GC	112
ZNF3	107
TG	88
APOB	87
UGT1A1	86
SH3RF1	84
ADAM29	81
KIAA1712	81
MTERFD2	73
EPHA4	73
HDAC4	73
LOC100129675	73
MYEOV2	73
NDUFA10	73
COL6A3	72
COPS8	72
VEGFC	69
ACCN4	68
DES	68
SLC4A3	68
TMEM198	68
TTLL4	67
CDH1	67
FN1	67
RNF25	67
TLL1	66
RNMT	65
TKTL2	65
ANP32C	63
LOC100128186	62
NEIL3	61
TMBIM1	61
ERBB4	60
SLC6A3	60
SPHKAP	60
TERT	60
PALLD	58
PLEKHG4B	57
ZNF519	56
XRCC5	55
CA2	53

The bold row signifies “VEGFC” a gene that was simulated to be one of the causal genes in GAW17 data.

ISSN: 1753-6561