From: Strategies for selection of subjects for sequencing after detection of a linkage peak
Strategy | Case subjects (n) | Case genotype countsa | Control subject genotype countsa | Dominant model | Recessive model | ||
---|---|---|---|---|---|---|---|
 |  |  |  | Effect size | Benefit-cost ratio | Effect size | Benefit-cost ratio |
Strategies focused on age | Â | Â | Â | Â | Â | Â | Â |
A. Youngest haplotype-carrier case per pedigree | 8 | 5/1/2 | 15/100/87 | 2.27 | 0.28 | 20.78c | 2.60 |
B. Youngest case per pedigree | 8 | 4/4/0 | 15/100/87 | 12.1b,c | 1.51 | 12.47c | 1.56 |
Strategies focused on low-covariate status | Â | Â | Â | Â | Â | Â | Â |
C. All low-covariate haplotype-carrier case subjects | 13 | 7/5/1 | 15/100/87 | 9.08c | 0.70 | 14.54c | 1.12 |
D. Families with 2+ low-covariate haplotype-carrier case subjects | 9 | 4/4/1 | 15/100/87 | 6.05 | 0.67 | 9.97c | 1.11 |
E. All low-covariate case subjects | 16 | 7/6/3 | 15/100/87 | 3.28 | 0.21 | 9.7c | 0.61 |
F. Lowest covariate case subject per pedigree | 8 | 3/4/1 | 15/100/87 | 5.3 | 0.66 | 7.48c | 0.94 |
Other strategies | Â | Â | Â | Â | Â | Â | Â |
G. All haplotype-carrier case subjects per pedigree | 40 | 10/21/9 | 15/100/87 | 2.61 | 0.07 | 4.16c | 0.10 |
H.All case subjects | 81 | 10/40/31 | 15/100/87 | 1.22 | 0.02 | 1.76 | 0.02 |
I. Random case subject per pedigree | 8 | 0/5/3 | 15/100/87 | 1.26 | 0.16 | 0 | 0.00 |