BMC Proceedings

Table 1 Distribution of causal minor alleles of Q1 and Q2 in the eight simulated pedigrees

From: Enriching rare variants using family-specific linkage information

Gene	Family								Founder
	1	2	3	4	5	6	7	8	Yes	No
Q1
ARNT	3	2	0	0	6	0	0	0	4	7
ELAVL4*	0	0	1	0	0	0	0	0	1	0
FLT1	0	0	5	0	28	16	13	12	28	46
FLT4	0	0	0	0	0	0	0	0	0	0
HIF1A*	0	0	0	0	1	0	0	0	1	0
HIF3A*	0	0	0	0	3	0	0	0	1	2
KDR	14	37	43	31	6	0	93	0	55	169
VEGFA*	4	20	0	0	0	0	22	0	3	43
VEGFC*	0	0	0	0	0	0	31	0	1	30
Q2
BCHE	4	0	0	0	1	0	2	2	5	4
GCKR*	2	0	0	0	0	0	0	0	1	1
INSIG1	0	0	0	0	0	0	0	0	0	0
LPL	7	20	2	1	0	1	23	7	15	46
PDGFD*	0	0	0	0	0	0	2	0	1	1
PLAT	0	1	2	0	0	3	0	0	4	2
RARB	0	0	0	0	0	0	0	0	0	0
SIRT1	0	0	3	0	0	4	21	0	4	24
SREBF1	16	21	0	5	9	12	8	0	13	58
VLDLR	2	0	0	0	11	0	6	0	4	15
VNN1	35	60	27	15	24	17	77	0	54	201
VNN3	24	17	27	0	21	0	42	42	46	127
VWF	0	0	0	2	0	0	0	0	2	0

Asterisks indicate a single nonmonomorphic causal variant in the gene.

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ISSN: 1753-6561

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