Old lessons learned anew: family-based methods for detecting genes responsible for quantitative and qualitative traits in the Genetic Analysis Workshop 17 mini-exome sequence data

Table 1 Linkage analyses using classic methods in replicate 1

	Haseman-Elston regression
Gene	Sib pairs	Grandparent-grandchild pairs	Lander-Green (Merlin)	Elston-Stewart (FastLink)
Qualitative trait
False positives	0 (0)	0 (2)	0 (0)	NA
Quantitative trait Q1
VEGFA	0 (0)	0 (0)	0 (1)	1 (0)
VEGFC	0 (0)	0 (0)	0 (0)	1 (0)
False positives	0 (0)	0 (6)	0 (3)	NA
Quantitative trait Q2
False positives	0 (0)	0 (0)	0 (0)	NA
Quantitative trait Q4
False positives	0 (7)	0 (2)	0 (1)	NA

Number of signals detected at genome-wide significant levels, with suggestive levels in parentheses.

ISSN: 1753-6561