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Volume 6 Supplement 3

Metabolism, diet and disease

  • Oral presentation
  • Open Access

Regulation of nutrient metabolism by nuclear receptor/FGF signaling pathways

  • 1 and
  • 1
BMC Proceedings20126 (Suppl 3) :O16

  • Published:


  • Lipid
  • Growth Factor
  • Signaling Pathway
  • Recent Work
  • Metabolic Disease

The regulation of metabolism in fed and fasted states is governed by hormonal and nutrient-derived signals that are mediated in part by nuclear receptors. Just as insulin and glucagon help the body store and mobilize energy through their membrane receptors, nutrient-derived lipids activate their cognate nuclear receptors (e.g., FXR and PPARs) to govern transcriptional programs involved in energy storage and utilization during times of nutrient excess and privation. Recent work has revealed that many of the actions of these nuclear receptors are mediated by two atypical fibroblast growth factors (FGF19 and FGF21) that function as endocrine-like hormones. The characterization of these pathways in normal and metabolic disease animal models has led to an understanding of their physiologic and pharmacologic mechanism of action.

Authors’ Affiliations

Department of Pharmacology and the Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA


© Kliewer and Mangelsdorf; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.