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Volume 6 Supplement 3

Metabolism, diet and disease

Growth control and metabolism

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mTOR is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that regulates cell growth and proliferation. We now appreciate that this pathway becomes deregulated in many human cancers and has an important role in the control of metabolism and aging. We have identified two distinct mTOR-containing proteins complexes, one of which regulates growth through S6K and another that regulates cell survival through Akt. These complexes, mTORC1 and mTORC2, define both rapamycin-sensitive and insensitive branches of the mTOR pathway. I will discuss new results from our lab on the regulation and functions of the mTORC1 and mTORC2 pathways.

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Correspondence to David M Sabatini.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sabatini, D.M. Growth control and metabolism. BMC Proc 6, O22 (2012) doi:10.1186/1753-6561-6-S3-O22

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  • Public Health
  • Signaling Pathway
  • Cell Growth
  • Cell Survival
  • Protein Complex