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The in vivofunction of the p53 target gene TIGAR
BMC Proceedings volume 6, Article number: P12 (2012)
The p53 tumour suppressor inhibits tumour development via various mechanisms such as apoptosis, inhibition of proliferation or the activation of senescence. Recently, several studies have indicated a novel role of p53 in the regulation of energy metabolism. Previously we have discovered TIGAR, a p53 target gene that acts as a fructose-2,6-bisphosphatase. TIGAR therefore can redirect glucose from the glycolytic pathway to the pentose phosphate pathway (PPP), which promotes NADPH production to generate reduced glutathione for protecting against ROS, and also ribose 5 phosphate production for nucleotide synthesis. In order to understand the function of TIGAR in vivo, we generated TIGAR deficient mice. We have determined a critical role of TIGAR in rapidly proliferating tissue, either for repair after damage or during tumor development.
This work was supported by Cancer Research UK; ECC is supported by a Canadian Institutes of Health Research fellowship.
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Cheung, E.C., Athineos, D., Ridgway, R. et al. The in vivofunction of the p53 target gene TIGAR. BMC Proc 6, P12 (2012). https://doi.org/10.1186/1753-6561-6-S3-P12
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