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BMC Proceedings

Volume 6 Supplement 3

Metabolism, diet and disease

Open Access

Cellular metabolic response to DNA damage

  • Seung Min Jeong1 and
  • Marcia C Haigis1
BMC Proceedings20126(Suppl 3):P24

Published: 1 June 2012


GlutamineCell Cycle ArrestMetabolic ResponseCellular MetabolismCellular Signaling

DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA repair. The metabolic response to DNA damage is largely unknown. Here we report a novel metabolic response to genotoxic stress. DNA damage triggers a critical block in the uptake of glutamine, a mitochondrial substrate essential for cellular proliferation. Sirtuins regulate both cellular metabolism and stress responses. We found mitochondrial SIRT4 is involved in the metabolic response to DNA damage. These results suggest that the metabolic adaptation is important for cellular DNA damage response.

Authors’ Affiliations

Department of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, USA


© Jeong and Haigis; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.