Introduction
Increased intraocular pressure (IOP) is a major risk factor for developing ocular disease such as primary open-angle glaucoma. Plasminogen activator inhibitor 1 (PAI-1) plays a role in the turnover and degradation of extracellular matrix proteins (ECM) which are thought to play a role in the pathogenesis of increased IOP. To determine if an independent association exists between serum PAI-1 and IOP in humans.