Introduction
An increasing body of evidence suggests a synergistic link between infection/inflammation and hypoxia-ischaemia in the pathogenesis of perinatal brain injury. Deletion of the TNF cytokine gene cluster (TNF, LTα and LTβ) has previously been shown to abolish lipopolysaccharide (LPS)-mediated sensitisation of the developing brain to hypoxic-ischaemic (HI) insult. In this study, I investigated if single TNF and LTβ gene deletions prevented LPS-sensitised HI brain injury.