Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococcus (VRE) have accomplished important rates of colonization and infection in most intensive care units. These multidrug-resistant strains of MRSA and VRE have been causing serious problems in health care. The rising clinical importance of drug-resistant pathogens has lent necessity to drug development research. In recent years, many 1H-indole derivatives including also Schiff base structures have been reported to exhibit chemotherapeutic properties such as antiviral, anti-tuberculosis, antifungal, and antibacterial activity. Hydrazone-type compounds containing an azomethine also represent a significant class of compounds for new drug development. The hydrazone group in molecules has an essential role in antimicrobial activity. It has been claimed that a number of hydrazide-hydrazone derivatives possess interesting antibacterial-antifungal and antituberculosis activities.