Volume 6 Supplement 4

International Conference for Healthcare and Medical Students 2011

Open Access

The prevalence of metabolic syndrome up to 5 years post-partum in patients with a history of gestational diabetes mellitus

  • C Crowe1,
  • E Noctor1,
  • LA Carmody1,
  • B Wickham1,
  • G Avalos1,
  • G Gaffney2,
  • P O’Shea3,
  • F Dunne1 and
  • the ATLANTIC DIP Collaborators
BMC Proceedings20126(Suppl 4):P44

https://doi.org/10.1186/1753-6561-6-S4-P44

Published: 9 July 2012

Introduction

Metabolic syndrome (MetS) is associated with cardiovascular mortality and increased risk of type 2 diabetes.

Methods

We examine the prevalence of MetS in a cohort of Caucasian women with previous gestational diabetes (GDM) (n=116), and those with normal glucose tolerance (NGT) during pregnancy (n=51). Fasting glucose alone (known DM/pre-diabetes post-partum patients) or 75g OGTT (other patients), lipid profile, insulin and c-peptide were performed. We calculated insulin resistance using the HOMA2-IR computer model.

Results

Table 1

 

Number with MetS (ATPIII criteria) (%)

Mean HOMA-2IR (+/- SD)

Number with HOMA-2IR>1.7 (%)

DM/pre-diabetes post GDM (n=33)

12 (36%)

1.21(+/-0.77)

18 (55%)

NGT post GDM (n= 83)

11 (13%)

1.93(+/-1.4)

18 (22%)

No history GDM (n=52)

3 (6%)

1.02(+/-0.85)

6 (13%)

Conclusions

Metabolic syndrome and insulin resistance are significantly more prevalent in Caucasian patients with GDM progressing to post-partum DM/pre-diabetes than those who do not (p<0.01), suggesting a need to target lifestyle changes in the early post-partum period to help prevent progression to T2DM.

Authors’ Affiliations

(1)
Department of Medicine, University Hospital Galway and National University of Ireland
(2)
Department of Obstetrics and Gynaecology, University Hospital Galway
(3)
Department of Clinical Biochemistry, University Hospital Galway

Copyright

© Crowe et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Advertisement