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The prevalence of metabolic syndrome up to 5 years post-partum in patients with a history of gestational diabetes mellitus
BMC Proceedings volume 6, Article number: P44 (2012)
Introduction
Metabolic syndrome (MetS) is associated with cardiovascular mortality and increased risk of type 2 diabetes.
Methods
We examine the prevalence of MetS in a cohort of Caucasian women with previous gestational diabetes (GDM) (n=116), and those with normal glucose tolerance (NGT) during pregnancy (n=51). Fasting glucose alone (known DM/pre-diabetes post-partum patients) or 75g OGTT (other patients), lipid profile, insulin and c-peptide were performed. We calculated insulin resistance using the HOMA2-IR computer model.
Results
Conclusions
Metabolic syndrome and insulin resistance are significantly more prevalent in Caucasian patients with GDM progressing to post-partum DM/pre-diabetes than those who do not (p<0.01), suggesting a need to target lifestyle changes in the early post-partum period to help prevent progression to T2DM.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Crowe, C., Noctor, E., Carmody, L. et al. The prevalence of metabolic syndrome up to 5 years post-partum in patients with a history of gestational diabetes mellitus. BMC Proc 6 (Suppl 4), P44 (2012). https://doi.org/10.1186/1753-6561-6-S4-P44
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DOI: https://doi.org/10.1186/1753-6561-6-S4-P44