The prevalence of metabolic syndrome up to 5 years post-partum in patients with a history of gestational diabetes mellitus
© Crowe et al; licensee BioMed Central Ltd. 2012
Published: 9 July 2012
Metabolic syndrome (MetS) is associated with cardiovascular mortality and increased risk of type 2 diabetes.
We examine the prevalence of MetS in a cohort of Caucasian women with previous gestational diabetes (GDM) (n=116), and those with normal glucose tolerance (NGT) during pregnancy (n=51). Fasting glucose alone (known DM/pre-diabetes post-partum patients) or 75g OGTT (other patients), lipid profile, insulin and c-peptide were performed. We calculated insulin resistance using the HOMA2-IR computer model.
Number with MetS (ATPIII criteria) (%)
Mean HOMA-2IR (+/- SD)
Number with HOMA-2IR>1.7 (%)
DM/pre-diabetes post GDM (n=33)
NGT post GDM (n= 83)
No history GDM (n=52)
Metabolic syndrome and insulin resistance are significantly more prevalent in Caucasian patients with GDM progressing to post-partum DM/pre-diabetes than those who do not (p<0.01), suggesting a need to target lifestyle changes in the early post-partum period to help prevent progression to T2DM.
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