Volume 6 Supplement 4

International Conference for Healthcare and Medical Students 2011

Open Access

Predictors of long term outcomes of IgA nephropathy

  • U Kabir1,
  • T Rahman1,
  • D Connaughton1 and
  • P Conlon1
BMC Proceedings20126(Suppl 4):P50

https://doi.org/10.1186/1753-6561-6-S4-P50

Published: 9 July 2012

Introduction

IgA Nephropathy (IgAN) was first described by Berger and Hinglais in 1968. The correlations between clinical as well as histopathological features on presentation and disease progression still remain unclear.

Aim

To identify the key predictors of long term renal outcomes in IgAN.

Methods

Two hundred patients with biopsy proven IgAN were selected and their clinical as well as histopathological data was analysed for progression to End-stage renal disease (ESRD).

Results

98 patients were used as the selected cohort. 21.5% of patients developed ESRD within 5 years and 28.8% within 10 years. Univariate studies showed that interstitial fibrosis, glomerulosclerosis, presence of fibrocellular crescents, proteinuria (g/24hrs) and raised serum creatinine levels at the time of biopsy were significant. (P value of <0.001 and 95% CI considered significant.) In the multifactorial analysis interstitial fibrosis and raised serum creatinine, lost their significance. (P value of <0.05 and 95% CI considered significant.)

Conclusions

Combination of proteinuria, glomerulosclerosis and fibrocellular crescents may contribute to poor renal outcomes in patients with IgAN. Interstitial fibrosis and raised serum creatinine levels may have solitary effects on disease progression as well.

Authors’ Affiliations

(1)
Royal College of Surgeons in Ireland

Copyright

© Kabir et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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