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Volume 6 Supplement 6

Beyond the Genome 2012

The hunt for mammalian epialleles

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Epialleles are genomic loci at which the epigenetic state can stably vary amongst individuals of a given population. Although first described and still best understood in plants, in recent years we have come to realize that epigenomic landscapes in mammals can also show considerable inter-individual variation. Such mammalian epialleles could arise through genetic influences, or have non-genetic origins as a result of stochastic events, environmental factors such as exposure to a compromised in utero environment, or adult lifestyle-associated factors such as smoking. My lab is currently pursuing several complementary lines of investigation that integrate molecular genetics and epigenomics in mouse models and human cohorts to understand the role of epialleles in complex phenotypes and diseases. In my talk, I will present a synthesis of the latest findings from several ongoing studies in my lab on epiallelic variation in mammals.

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Correspondence to Vardhman Rakyan.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Public Health
  • Environmental Factor
  • Mouse Model
  • Molecular Genetic
  • Genomic Locus