Figure 5

Differential classification performance for diverse and self-similar annotation groups. The left column shows ROC for prediction of annotation within diverse groups of the three classification types, using pairwise distances from all three alignment methods and both MDS methods, and the right column shows ROC curves for prediction of annotation within homogeneous or self-similar groups. While MPSS proximity is an effective classifier for both diverse and self-similar groups of structures, pairwise distances do not perform well for diverse groups, regardless of alignment method. MPSS produced using SMACOF are especially successful for diverse groups, but may very slightly over-fit the positions of structures within homogeneous groups.