Figure 3
Pathways generated by lists of genes from the association analysis. A, Pathway analysis of top 40 statistically significant genes (p <3.5 × 10−5) derived from the union of the genes across all 5 phenotypes, MIPA = 70. Pathway score = 77, corresponding to p = 10−77. This was the only statistically significant pathway obtained for this set of genes. Molecules in red correspond to genes (N = 30, 75%) from the input list of 40. Functional annotations for this pathway include cell death and survival, gastrointestinal disease, and inflammatory disease. B, Pathway analysis of the top 38 statistically significant genes (p <1.0 × 10−4) derived from the hypertension phenotype, MIPA = 70. Pathway score = 62, corresponding to p = 10−62. This was the only statistically significant pathway obtained for this set of genes. Molecules in red correspond to genes (N = 25, 66%) from the input list of 38. Functional annotations for this pathway include cellular assembly and organization, cellular function and maintenance, and cell death and survival.