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Table 2 Top 15 genes influencing simulated SBP and DBP

From: Data for Genetic Analysis Workshop 18: human whole genome sequence, blood pressure, and simulated phenotypes in extended pedigrees

Gene

Chromosome

Position of first functional SNP (bp)

Total variance explained (%)

Variance explained by largest functional variant (%)

Number of functional variants

DBP

     

MAP4

3

47912898

6.48

2.29

15

TNN

1

174996637

4.08

1.98

18

NRF1

7

129252980

2.65

1.08

14

LEPR

1

65912722

2.50

2.19

8

FLT3

13

28567172

1.22

1.01

10

ZFP37

9

115803080

0.92

0.49

9

CGN

1

151491026

0.83

0.60

16

MTRR

5

7870973

0.36

0.10

11

SLC35E2

1

1658093

0.36

0.14

7

ZNF443

19

12513424

0.34

0.26

13

RAI1

17

17498492

0.32

0.30

7

PTTG1IP

21

46266768

0.28

0.16

7

CABP2

11

67288594

0.21

0.21

1

ZNF544

19

58740339

0.21

0.18

9

REPIN1

7

150041836

0.20

0.10

6

SBP

     

MAP4

3

47912898

7.79

2.79

15

NRF1

7

129252980

4.67

1.91

14

TNN

1

174996637

3.87

1.89

16

LEPR

1

65912722

2.23

2.06

8

FLT3

13

28567172

0.97

0.82

8

GTF2IRD1

7

73822336

0.36

0.10

10

FLNB

3

58089761

0.29

0.27

8

ZNF443

19

12513424

0.22

0.17

11

GSN

9

123969834

0.21

0.09

13

CABP2

11

67288594

0.17

0.17

1

LRP8

1

53712727

0.17

0.17

2

PSMD5

9

123575167

0.16

0.13

6

GAB2

11

77935643

0.14

0.08

4

ABTB1

3

127394820

0.13

0.10

2

KRTAP11-1

21

3225351

0.13

0.13

1

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BMC Proceedings

ISSN: 1753-6561

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