Table 3 Genome-wide rare-variant analysis top findings
From: Rare genetic variant analysis on blood pressure in related samples
Gene-based analysis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
famBT | famSKAT | |||||||||
Trait | Gene | Chr | Position | N SNPs | p value | Gene | Chr | Position | N SNPs | p value |
DBP | OR2L13 | 1 | 248100493-248264224 | 5 | 1.8 × 10−5 | GLIS1 | 1 | 53971906-54199877 | 6 | 1.1 × 10−4 |
DBP | TRAF1 | 9 | 123664671-123691451 | 2 | 1.3 × 10−4 | OR2L13 | 1 | 248100493-248264224 | 5 | 1.6 × 10−4 |
DBP | TRIM25 | 17 | 54965270-54991409 | 3 | 4.2 × 10−4 | DAZL | 3 | 16628299-16647006 | 3 | 2.1 × 10−4 |
SBP | KRT14 | 17 | 39738531-39743147 | 4 | 6.5 × 10−5 | GTF2H2 | 5 | 70330951-70363497 | 1 | 8.8 × 10−5 |
SBP | GTF2H2 | 5 | 70330951-70363497 | 1 | 7.3 × 10−5 | ERC2 | 3 | 55542336-56502391 | 5 | 6.9 × 10−4 |
SBP | ACADVL | 17 | 7120444-7128586 | 8 | 3.5 × 10−4 | PCDHB4 | 5 | 140501581-140505201 | 7 | 1.1 × 10−3 |
Sliding-window analysis | ||||||||||
DBP | CTTNBP2* | 7 | 117615273 | 14 | 1.6 × 10−6 | MIR583* | 5 | 95537956 | 13 | 3.8 × 10−6 |
DBP | ITLN2 | 1 | 160920490 | 18 | 1.9 × 10−6 | NRCAM | 7 | 107823273 | 17 | 7.1 × 10−6 |
DBP | MYO7A | 11 | 76873460 | 20 | 3.6 × 10−6 | INO80 | 15 | 41308350 | 10 | 1.1 × 10−5 |
SBP | LOC201617* | 3 | 72074162 | 16 | 1.6 × 10−6 | PRKCA | 17 | 64294080 | 14 | 3.0 × 10−6 |
SBP | LUC7L3* | 17 | 48832080 | 16 | 1.6 × 10−6 | GUCY1A2* | 11 | 106349460 | 16 | 1.9 × 10−5 |
SBP | PSIP1 | 9 | 15472910 | 15 | 2.6 × 10−6 | MIR548H3 | 9 | 78272910 | 18 | 1.6 × 10−5 |