Use of admixture and association for detection of quantitative trait loci in the Type 2 Diabetes Genetic Exploration by Next-Generation Sequencing in Ethnic Samples (T2D-GENES) study

Table 3 Parameter estimates for model 4 at the significant marker rs12639065 for log(DBP)

Factors	Parameter estimate	Standard error	P-value (Pr >\|t\|)	N ¹
Intercept	4.162	0.047	<2 × 10 ^-16
Proportion Native American (NA) Global Ancestry	-0.099	0.063	0.116
Proportion African Global Ancestry	-0.325	0.024	0.118
Indicator for blood pressure medication use	0.124	0.024	1.32 × 10 ^-6
D_EN Indicator for European and NA local ancestry (LA)	0.138	0.047	0.004	67
D_EA European and African LA	-0.053	0.083	0.526	5
D_NN Native American LA	0.145	0.049	0.004	26
D_NA Native American and African LA	0.131	0.086	0.132	4
g × D_EE Stratified genotype: European LA	0.123	0.030	9.06 × 10 ^-5	30
g × D_EN Stratified genotype: European and NA LA	0.049	0.022	0.026	67
g × D_EA Stratified genotype: European and African LA	-0.039	0.103	0.707	5
g × D_NN Stratified genotype: Native American LA	-0.069	0.037	0.064	26
g × D_NA Stratified genotype: Native American and African LA	-0.122	0.109	0.264	4

Bold type indicates p-values less than 0.05.
¹Sample size after stratifying for local ancestry at the marker, e.g., 67 of the unrelated individuals had European and Native American ancestral alleles at rs12639065.

ISSN: 1753-6561