A powerful statistical method identifies novel loci associated with diastolic blood pressure triggered by nonlinear gene-environment interaction

Table 1 List of SNPs with p value <5 × 10⁻⁷

rs ID	Gene name	Chr	$p_{41}$	$p_{31}$	$p_{21}$	$p_{42}$	$p_{43}$
rs1086097	MIR1263	3	1.9 × 10⁻⁷	0.009	0.90	4.97 × 10⁻⁸	1.08 × 10⁻⁶
rs686697	MIR1263	3	3.4 × 10⁻⁷	0.005	0.76	9.24 × 10⁻⁸	3.41 × 10⁻⁶
rs483558	unknown	3	4.7 × 10⁻⁷	0.007	0.76	1.30 × 10⁻⁷	3.72 × 10⁻⁶
rs9863717*	unknown	3	4.96 × 10⁻⁸	0.009	0.95	1.23 × 10⁻⁸	2.55 × 10⁻⁷
rs1575160*	unknown	3	8.7 × 10⁻⁸	0.011	0.70	2.33 × 10⁻⁸	3.76 × 10⁻⁷
rs723877	UNC13B	9	4.3 × 10⁻⁷	1.25 × 10⁻⁶	2.37 × 10⁻⁵	6.1 × 10⁻⁴	0.02
rs10972462*	UNC13B	9	9.5 × 10⁻⁸	6.96 × 10⁻⁷	1.31 × 10⁻⁵	2.3 × 10⁻⁴	0.007

*Indicates significant SNPs after Bonferroni correction. $p_{41}$ , $p_{31},$ and $p_{21}$ are p values for testing $H_{0}^{3} : β (X) = 0$ (mean model 4 vs. mean model 1), $H_{0}^{2} : β_{0} = β_{1} = 0$ (mean model 3 vs. mean model 1), and $H_{0}^{1} : β = 0$ (mean model 2 vs. mean model 1), respectively; $p_{42}$ and $p_{43}$ are p values for testing $H_{0} : β (X) = β_{0}$ and $H_{0} : β (X) = β_{0} + β_{1} X,$ respectively. Small values of $p_{42}$ and $p_{43}$ indicate nonlinear G × E effect. The small p values for those 3 SNPs with unknown gene names in chromosome 3 are in high linkage disequilibrium with those in gene MIR1263.

ISSN: 1753-6561