Hierarchical linear modeling of longitudinal pedigree data for genetic association analysis

BMC Proceedings

Table 1 The top 10 SNPs (MAF >0.01) detected with the highest statistical power from simulated data

			SBP(42)		Rate of change		Closest functional variants in simulation
SNP	Position	MAF	Power α = 0.05	Beta mean	Power α = 0.05	Beta mean	Position	MAF	Beta	% Variance
rs11711953	48040283	0.03	1.00	−18.6	0.75	0.59	48042083, 48042084	0.03 0.01	−9.91 −11.01	0.028 0.011
rs1665982	47905079	0.11	0.64	−6.08	0.46	0.25	48042083, 48042084, 47913455	0.03 0.01 0.005	−9.91 −11.01 −8.70	0.028 0.011 0.004
rs319680	47898307	0.15	0.53	−4.60	0.41	0.20	47913455	0.005	−8.70	0.004
rs6763824	47905427	0.14	0.46	−4.47	0.38	0.20	47913455	0.005	−8.70	0.004
rs184388	47939626	0.34	0.40	−3.03	0.33	0.13	47956424	0.38	−2.38	0.014
rs1060407	47958037	0.34	0.39	−3.02	0.33	0.13	47957996, 47957741	0.03 0.002	−7.39 −8.10	0.015 0.003
rs7430879	48038714	0.38	0.39	−2.82	0.39	0.13	48042083, 48042084	0.03 0.01	−9.91 −11.01	0.028 0.011
rs4599334	48066400	0.35	0.37	−2.93	0.29	0.12	48042083, 48042084	0.03 0.01	−9.91 −11.01	0.028 0.011
rs4296617	48068308	0.35	0.37	−2.92	0.28	0.12	48042083, 48042084	0.03 0.01	−9.91 −11.01	0.028 0.011
rs2053767	47999674	0.38	0.37	−2.75	0.38	0.13	48042083, 48042084	0.03 0.01	−9.91 −11.01	0.028 0.011

ISSN: 1753-6561