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BMC Proceedings

Open Access

Micellar systems of poloxamer 407 and 403 for quercetin delivery

  • Juscemácia Araujo1 and
  • Daniele Araujo1
BMC Proceedings20148(Suppl 4):P75

https://doi.org/10.1186/1753-6561-8-S4-P75

Published: 1 October 2014

The use of poloxamers (PL) have been one of the most widely strategies used for drug delivery systems. The copolymer Poloxamer 407 is a non-ionic surfactant consisting of polioxyethylene (POE) and polioxypropylene (POP) that has many pharmaceutical applications due to its thermoreversible properties. PL are biocompatible and for this reason, are very attractive as carrier systems for administration by different routes, including topical.

This work aimed the development with emphasis on physicohemical characterization of PL hydrogels for quercetin, being a useful strategy to expand the therapeutic application of these compounds as active ingredients in pharmaceutical formulations designed for topical use.1, 2 In the first stage this work was carried out to study the physico-chemical characteristics of quercetin and evelopment of formulations containing PL gels 407 (28% to 30%) and PL 403 (2%) associated to solubilizing agents polyethyleneglycol 600 (PEG 600) and propyleneglycol (PPG).

Systems with higher linearity suggest that PL hydrogels were efficient for permeation across artificial membranes. Besides, thermodynamic profile was obtained from Differential Scanning Calorimetry (DSC) assays, best values of enthalpy (0.580 J / g) and Gibb's free energy (-12245.95 J.K1.mol-1) were observed for the system PL 407-PEG 600, showing that PL system present spontaneous micellization, stability and thermorreversibility for quercetin delivery.

Authors’ Affiliations

(1)
Universidade Federal do ABC

References

  1. Yang X, Wu D, Du Z, R Li, Chen X, Li X: Spectroscopy Study on the Interaction of Quercetin with Collagen. J Agric Food Chem. 2009, 57 (9): 3431-3435.View ArticlePubMedGoogle Scholar
  2. Parmar A, Singh K, Bahadur A, Marangoni G, Bahadur P: Interaction and solubilization of some phenolic antioxidants in Pluronic® micelles. Colloids and Surfaces B: BioInterfaces. 2011, 86 (2): 319-326.View ArticlePubMedGoogle Scholar

Copyright

© Araujo et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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