Background
Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide. Currently, tumor-node-metastasis staging system still remains the gold standard for prognosis of CRC patients, but it is no longer sufficient. Among the most important molecules involved in colorectal tumor growth, cell proliferation and progression are adhesive molecules such as CD44 and E-cadherin (EC). The aim of this study was to evaluete the expression of CD44 standard protein and EC in correlation with Ki-67 proliferative index and some other clinicopathological prognostic variables in patients with CRC.