Figure 1

Multipotent haematopoietic stem cell pathway associated with the production of different blood cell lineages. The highlighted gene in colour is associated with neutrophil production (SCF, TPO, G-CSF, IL-3, IL-5). These genes need to be investigated further to screen for any mutations that could result in an aberrant gene which could inhibit the synthesis of neutrophils leading to a lower neutrophil count. EPO (erythropoietin - cytokine), G-CSF (colony stimulating factor 3 (granulocyte) - cytokine), GM-CSF (colony stimulating factor 2 (granulocyte-macrophage) – cytokine), IL-15 (interleukin 15 – cytokine), IL-2 interleukin 2 – (cytokine), IL-3 interleukin 3 – (cytokine), IL-4 (interleukin 4 – (cytokine), IL-5 (IL-5 interleukin 5 – (cytokine), IL-7 (interleukin 7 – (cytokine), M-CSF colony stimulating factor 1 (macrophage) - cytokine, SCF (KIT ligand) – growth factor, TPO (thrombopoietin) – cytokine.