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Trigger finger genetics and its tendon pathology

The pathogenesis of trigger finger has generally been ascribed to primary changes in the first annular ligament. In contrast, we recently found histological changes in the tendons, similar to the findings in Achilles tendinosis. When we looked further for more similarities we found differences in gene expression in the trigger finger tendons in comparison to normal tendons, in a pattern similar to what is published for Achilles tendinosis. We also found SNP (Single Nucleotide Polymorphism) pattern difference with similarities with what is published for Achilles tendinosis.

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Correspondence to Anna-Carin Lundin.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Keywords

  • Public Health
  • Gene Expression
  • Nucleotide
  • Single Nucleotide Polymorphism
  • Histological Change