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Figure 1 | BMC Proceedings

Figure 1

From: Implementation of a quality by design approach into cell line and process development for recombinant protein production

Figure 1

A) Six clones derived from cell pool LPB were analyzed for fed-batch performance and protein quality attributes of the model IgG1 antibody. B) Effective clone selection as well as media and process optimization enables to match the N-glycosylation pattern of a reference protein. C) Scalability of the fed-batch process from shake flask to bioreactor scale has been demonstrated for different clones and is exemplarily shown for an IgG1 antibody.

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BMC Proceedings

ISSN: 1753-6561

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